Influence of astragaloside IV on pharmacokinetics of triptolide in rats and its potential mechanism

Figures & data

Figure 1. The pharmacokinetic profiles of triptolide in rats after the oral administration of 2 mg/kg triptolide with or without AS-IV pre-treatment.

Table 1. Pharmacokinetic parameters of triptolide in rats after oral administration of triptolide (2 mg/kg; n = 6, mean ± SD) with and without treatment of AS-IV.

Parameter	Control	Pre-treatment of AS-IV
Tmax (h)	0.26 ± 0.08	0.23 ± 0.03
Cmax (μg/L)	418.78 ± 29.36	351.31 ± 38.88
t1/2 (h)	0.45 ± 0.08	0.52 ± 0.12
AUC (0-t) (μg h L^−1)	358.83 ± 19.56	252.23 ± 15.75*
CL (L/h/kg)	5.59 ± 0.31	7.95 ± 0.51*

*p < 0.05 indicates significant differences compared with the control.

Figure 2. The effects of AS-IV on the bidirectional transport of triptolide from the apical to basolateral side (A) or in the opposite direction (B). Caco-2 cell monolayers were incubated at 37 °C in HBSS (pH 7.4), and triptolide (25 μM) was added to the donor chamber of the Caco-2 cell monolayer. Each point represents the mean ± SD of three determinations.