Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism

Figures & data

Figure 1. Plasma concentration–time curves of valsartan in the presence or the absence of 4 or 10 mg/kg ligustrazine.

Table 1. Pharmacokinetic parameters of valsartan (10 mg/kg) with or without ligustrazine (4 or 10 mg/kg).

	Valsartan	Valsartan +  ligustrazine (4 mg/kg)	Valsartan +  ligustrazine (10 mg/kg)
AUC(0-t) (μg/L*h)	851.64 ± 104.26	385.37 ± 93.05*	249.85 ± 41.27*
t1/2 (h)	6.34 ± 1.25	5.46 ± 0.93*	5.15 ± 0.88*
Tmax (h)	3.88 ± 0.13	1.79 ± 0.22*	1.83 ± 0.19*
Cmax (μg/L)	83.87 ± 6.15	62.64 ± 9.09*	51.28 ± 2.67*
Clz/F (L/h/kg)	10.92 ± 1.52	25.76 ± 6.24*	39.44 ± 6.53*

* p < 0.05.