Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism

Figures & data

Figure 1. The mean plasma concentration-time curve of bavachin with or without the pre-treatment of pachymic acid. Pachymic acid significantly influenced the pharmacokinetic profile of bavachin.

Table 1. Pharmacokinetic parameters of bavachin with or without the presence of pachymic acid.

	Bavachin	Bavachin + pachymic acid
AUC(0–t) (μg/L*h)	19.43 ± 3.26	32.82 ± 4.61*
t1/2 (h)	2.32 ± 0.28	3.21 ± 0.65*
Tmax (h)	1.78 ± 0.23	0.97 ± 0.11*
Cmax (μg/L)	3.03 ± 0.19	5.40 ± 0.33*
CLz/F (L/h/kg)	523.81 ± 88.67	307.25 ± 44.35*

*p < 0.05.

Figure 2. Effect of pachymic acid on the transport of bavachin in Caco-2 model. Pachymic acid significantly inhibited the efflux of bavachin due to the decrease in the value of Papp_BA. ***p < 0.001.

Figure 3. Effect of pachymic acid on the activity of CYP2C9. Pachymic acid inhibited the activity of CYP2C9 in a dose-dependent manner with the IC₅₀ value of 21.25 µM.