Pharmacokinetic study on the interaction between succinic acid and irbesartan in rats and its potential mechanism

Figures & data

Figure 1. The plasma concentration-time curve of irbesartan (30 mg/kg) in the presence or absence of succinic acid (200 mg/kg).

Table 1. Pharmacokinetic parameters of 30 mg/kg irbesartan in the presence or absence of 200 mg/kg succinic acid.

	Irbesartan	Irbesartan + succinic acid
AUC (0–t) (μg/L*h)	3340.23 ± 737.75	5328.71 ± 959.31***
t1/2 (h)	12.79 ± 0.73	20.59 ± 6.35**
Tmax (h)	3.83 ± 1.10	2.83 ± 0.75*
CL/F (L/h/kg)	6.91 ± 1.65	3.46 ± 1.13*
Cmax (μg/L)	210.33 ± 26.08	315.3 ± 24.35**

*p < 0.05, *p < 0.01, ***p < 0.001.

Figure 2. The effect of succinic acid (0, 2.5, 5, 10, 25, 50, and 100 μM) on the activity of CYP2C9 in rat liver microsomes.