Figures & data
Table 1. Formulation development of A. paniculata capsules.
Table 2. Andrographolide contents in A. paniculata capsules (data are expressed as means ± SD, n = 10).
Table 3. Characterization of the phytochemical constituents of A. paniculata powder.
Table 4. Tolerability profile after oral administration of A. paniculata preparations (equivalent to 3 mg/kg of andrographolide).
Figure 2. (a–d). Comparative mean plasma concentration versus time profiles of andrographolide after single and multiple oral administration of A. paniculata alone and in different combination formulations (equivalent to 3 mg/kg of andrographolide) in beagle dogs. Data are presented as means ± SD (n = 4).
![Figure 2. (a–d). Comparative mean plasma concentration versus time profiles of andrographolide after single and multiple oral administration of A. paniculata alone and in different combination formulations (equivalent to 3 mg/kg of andrographolide) in beagle dogs. Data are presented as means ± SD (n = 4).](/cms/asset/5c2683c3-8efb-4096-beb5-fdfa2d30f34b/iphb_a_2311201_f0002_c.jpg)
Table 5. Comparative pharmacokinetic parameters of andrographolide after single and multiple oral administration of A. paniculata capsules (equivalent to 3 mg/kg of andrographolide) in beagle dogs.
Figure 3. Cumulative amount of andrographolide in urine after multiple oral administration of A. paniculata formulations (equivalent to 3 mg/kg of andrographolide) in beagle dogs. Data are presented as means ± SD (n = 4).
![Figure 3. Cumulative amount of andrographolide in urine after multiple oral administration of A. paniculata formulations (equivalent to 3 mg/kg of andrographolide) in beagle dogs. Data are presented as means ± SD (n = 4).](/cms/asset/5849be92-cae3-4384-9901-59738496047a/iphb_a_2311201_f0003_c.jpg)
Table 6. Percent recovery of andrographolide elimination in urine and feces after single and multiple oral administration of A. paniculata capsules (equivalent to 3 mg/kg of andrographolide) in beagle dogs (data are expressed as means ± SD, n = 4).
Data availability statement
The datasets generated and/or analyzed during the present study are not publicly available but are available from the corresponding author on reasonable request that needs a consensus from colleagues.