Oxidative stress during coronary artery bypass operations: Importance of surgical trauma and drug treatment

Figures & data

Table I.  Patient characteristics and perioperative data.

Age (Years)	63 (50–77)
Female/male	4/16
Smokers (ongoing)	2
Stable/unstable angina	16/4
Previous myocardial infarction	7
Two-vessel disease	5
Three-vessel disease	15
Acetylsalicylic acid (ASA)	19
ASA withdrawal ≤ 4 days	7
ASA withdrawal > 4 days	12
β-blocker	18
Ca channel blocker	7
Nitrates	10
ACE inhibitors	6
Statins	19
Low molecular heparin	5
Intraoperative heparin (IU)	43500 (37500–52500)
Cardiopulmonary bypass time (min)	63 (47–74)
Cross-clamp time (min)	36 (25–45)
Total operation time (min)	142 (123–174)

Data are presented as median values with percentiles (25^th and 75^th) in parentheses, or number of patients.

Figure 1.  Study design. The time course of operation and sampling is indicated.

Figure 2.  Changes in plasma 8-iso- PGF_2α. Blood samples were taken at various stages from a radial artery (closed symbols, t₀-t₁₄) and from the coronary sinus (open symbols, t₂-t₉). Median values with percentiles (25^th and 75^th) are shown. The results are correlated with albumin concentration.

Figure 3.  Changes in plasma 15-keto-dihydro-PGF_2α. Blood samples were taken at various stages from a radial artery (closed symbols, t₀-t₁₄) and from the coronary sinus (open symbols, t₂-t₉). Median values with percentiles (25^th and 75^th) are shown. The results are correlated with albumin concentration.

Figure 4.  Changes in plasma troponin T. Blood samples were taken at various stages from a radial artery (closed symbols, t₀-t₁₄) and from the coronary sinus (open symbols, t₂-t₉). Median values with percentiles (25^th and 75^th) are shown. The results are correlated with albumin concentration.