Analysis of the myocardial metabolism by microdialysis during open beating heart surgery

Figures & data

Table I.  Cardiovascular hemodynamic values. Data are presented as median±SEM. Heart rate (HR), mean arterial blood pressure (MAP), mean pulmonary arterial pressure (PAPM), central venous pressure (CVP), cardiac index (CI), end diastolic volume (EDV), systemic vascular resistance (SVR), mixed venous saturation of oxygen (SvO₂) before (prae 1/2), and after [15 min intervals, post 1–3] after anastomosis of the LAD.

	prae	prae	post	post	post	p-value
HR (bpm)	62.3±5.5	62.7±5.9	65.7±6.7	64.3±6.8	63.3±4.9	n.s.
MAP (mmHg)	88.8±13.6	89.2±20.7	90.0±11.2	80.9±13.5	77.7±14.1	n.s.
PAPM (mmHg)	29.1±7.7	29.9±8.5	30.0±9.2	22.9±7.0	22.7±4.7	n.s.
CVP (mmHg)	11.1±2.9	12.4±3.3	17.9±4.7	10.7±4.7	11.6±3.5	n.s.
CI (l*min^−1*m^2)	2.8±0.9	2.8±1.1	2.5±0.5	2.1±0.5	2.3±0.5	n.s.
EDV (ml)	233.5±72.1	229.0±60.1	219.2±67.3	198.4±24.2	201.4±33.8	n.s.
SVR (dynes×sec×cm^−5)	1280.9±466.7	1283.5±554.9	1317.0±495.1	1380.1±530.6	1275.9±414.8	n.s.
SVO2 (%)	73.8±2.5	73.4±3.4	71.1±6.4	74.2±6.2	74.8±7.2	n.s.

Figure 1.  Relative changes of the myocardial lactate and pyruvate levels before (prae 1–3) and after anastomosis of the LIMA (post 1–3; up to 45 min). During the early reperfusion a significant decrease of myocardial lactate and increase of pyruvate were observed (p < 0.05). Plasma values kept stable during the observation period.

Figure 2.  Relative changes of the myocardial glucose before (prae 1–3) and after anastomosis of the LIMA (post 1–3; up to 45 min). During the early reperfusion a significant increase of the glucose levels was found (p < 0.05). Plasma values kept stable during the observation period.

Figure 3.  Absolute changes of the myocardial hypoxanthine, inosine and adenosine before (prae 1–3) and after anastomosis of the LIMA (post 1–3; up to 45 min). During the early reperfusion a significant decrease of the purines was found (p < 0.05).