Survival after percutaneous coronary intervention and coronary artery bypass grafting in a single centre

Figures & data

Figure 1.  Kaplan-Meier estimate of unadjusted survival in the two strategy groups. The difference is not statistical significant (p = 0.93 – logrank test).

Table I.  Baseline characteristics.

Variable	PCI n = 6366	CABG n = 4449	p-value	Univariate HR (95% CI)
Age (mean±S.D.)	63.3±10.9	66.0±10.0	p < 0.001	1.53 (1.47–1.59)*
Female%	26.9	22.5	p < 0.001	1.00 (0.85–1.17)
EF% (mean±S.D.)	67.7±13.3	67.2±13.8	n.s.	0.72 (0.69–0.76)*
LVEDP mmHG (mean±S.D.)	13.4±4.9	14.2±5.6	p < 0.001	1.30 (1.21–1.40)*
Generalized arteriosclerosis%	2.8	5.0	p < 0.001	1.46(1.10–1.94)†
Other significant disease%	2.7	2.5	n.s	2.39 (1.75–3.28)‡
CCS functional class%
0	2.1	2.0		1
I	8.3	5.4		1.22 (0.50–3.22)
II	34.3	31.7		2.12 (0.94–4.8)
III	37.8	45.4		3.69 (1.65–8.26)
IV	17.5	15.5	p < 0.001	5.24 (2.32–11.8)
Unstable angina%	22.6	21.4	p = 0.068	1.65 (1.42–1.91)
Ischemia on EECG%	34.6	50.5	p < 0.001	0.65 (0.56–0.75)
Diabetes%	11.2	14.7	p < 0.001	1.54 (1.28–1.84)
Hypertension%	28.2	33.9	p < 0.001	0.98 (0.84–1.14)
Current smoker%	26.2	22.4	p < 0.001	0.81 (0.69–0.97)
Previous myocardial
infarction%	48.6	47.3	p = 0.177	1.64 (1.43–1.90)
Previous PCI%	14.9	7.8	p < 0.001	1.05 (0.85–1.30)
Previous CABG%	14.1	4.2	p < 0.001	1.71 (1.41–2.08)
Radial entry site%	84.2	83.9	n.s.	0.81 (0.71–0.92)
Coronary angiography
One vessel disease%	43.9	4.3		1
Two vessel disease%	30.4	18.0		1.33 (1.06–1.67)
Three vessel disease%	25.7	77.8	p < 0.001	2.21 (1.83–2.67)

Baseline characteristics are tested for differences between the strategies with Kruskal-Wallis test for continuous variables and χ² test or Fishers’ exact test as appropriate for categorical variables. LVEDP = left ventricular end diastolic pressure. CCS functional class = Canadian Cardiovascular Society functional class for angina. EF = left ventricular ejection fraction. EECG = exercise ECG. HR = hazard ratio. *HR for age is for 5 years difference, for EF% each 10% difference and LVEDP each 5 mm Hg difference. †Generalized arteriosclerosis was defined by previous extracardiac arteriosclerotic symptoms. ‡Other clinical significant renal, hepatic, pulmonary disease or significant obesity defined at the discretion of the treating physician.

Figure 2.  Survival curves from final Cox model in diabetics with one and two vessel disease. Hazard ratio for CABG versus PCI is 0.66 (99.5% CI 0.36–1.23). The difference is statistically of borderline significance (p = 0.064).

Figure 3.  Survival curves from final Cox model in non diabetics with three vessel disease. Hazard ratio for CABG versus PCI is 0.61 (99.5% CI 0.46–0.80). The difference is statistically different (p < 0.001, Bonferroni adjusted).

Figure 4.  Survival curves from final Cox model in diabetics with three vessel disease. Hazard ratio for CABG versus PCI is 0.40 (99.5% CI 0.24–0.67). The difference is statistically different (p < 0.001, Bonferroni adjusted).

Figure 5.  Estimated frequency of first reintervention between initial strategy and type of new intervention. The logrank test for initial strategy and any subsequent reintervention was highly significant (p < 0.001).