A model for left ventricular hypertrophy enabling non-invasive assessment of cardiac function

Figures & data

Figure 1.  Excised heart with silicone banding around the ascending aorta.

Figure 2.  (A) Short axis scan of a pig in the control group showing a left ventricle with normal thickness. (B) Short axis scan of a pig in the intervention group showing a left ventricle with increased thickness. (C) Doppler curve on a pig in the control group showing a transvalvular blood velocity of 1 m/s. (D) Doppler curve on a pig in the intervention group showing a transvalvular blood velocity of 4 m/s.

Table I.  Results from the follow-up and post mortem examinations: Midseptal thickness, Free wall thickness, Heart/Body Weight Ratio×1000 and Diameter of the cardiac myocytes. Results are displayed as mean±Standard Deviation.

	Intervention	Control
Midseptal thickness/cm
4 weeks	0.63±0.013	0.51±0.003	P = 0.03
6 weeks	0.69±0.016	0.62±0.003	P = 0.21
8 weeks	0.79±0.015	0.58±0.010	P = 0.01
Free wall thickness/cm
4 weeks	0.66±0.009	0.57±0.003	P = 0.05
6 weeks	0.73±0.012	0.63±0.010	P = 0.17
8 weeks	0.77±0.013	0.60±0.006	P = 0.01
Heart/Body Weight Ratio×1000
	7.73±0.97	6.23±0.43	P = 0.003
Diameter of the cardiac myocytes/µm
	19.6±4.9	11.0±1.9	P = 0.00