More than 20 years’ experience of left ventricular assist device implantation at a non-transplant Centre

Figures & data

Table 1. Demographics and aetiology, n (%).

	HMI n = xx (%)	HMII n = xx (%)	p	HMIII n = xx
Number of patients	16	30		3
Male	12 (75)	23 (77)	.91	1
Age, median years [range]	49 [15–63]	54 [26–62]	.23	59 [51–65]
Non-ischaemic cardiomyopathy	12 (75)	21 (70)	.73	2
Ischaemic cardiomyopathy	4 (25)	8 (27)	.91	1
Myocarditis	0	1 (3)	.49	0
Left ventricular heart failure	14 (87)	24 (80)	.54	2
Biventricular heart failure	2 (13)	6 (20)	.54	1
Previous cardiac surgery	3 (19)	7 (23)	.73	0
Previous myocardial infarction	4 (25)	10 (33)	.57	1
NYHA, median [range]	4 [3–4]	4 [3–4]	.73	3
Duration of heart failure, median years [range]	1.6 [0.03–12]	4 [0.02–21]	.35	4 [0.03–21]
Previous CVI	1 (6)	2 (7)	.69	0
Preoperative temporary assist device	2 (12)	4 (13)	.95	1
Preoperative mechanical ventilation	3 (19)	4 (13)	.64	1
Euroscore II, median [range]		9.4% [2.4–44.4]		25.5 [12–26]
INTERMACS level (median)	3	4	.07	3
Level 1 Critical cardiogenic shock, n (%)	2 (12)	4 (13)		1
Level 2 Progressive decline, n (%)	3 (19)	3 (10)		0
Level 3 Stable but inotrope dependent, n (%)	8 (50)	6 (20)		2
Level 4 Non-Inotrope dependent, n (%)	3 (19)	17 (57)		0

NYHA: New York Heart Classification; CVI: cerebrovascular insult.

Table 2. Postoperative outcome, n (%) or median days [range].

	HMI n = 16	HMII n = 30	p	HMIII n = 3
Mortality before Tx	1 (6)	7 (25)	.13
ICU-stay	15 [6–79]	15 [4–43]**	.59	9 [7–19]
Length of stay hospital	89 [37–249]	39 [14–105]**	.00006*	30 [20–32]
Pump time to Tx	232 [55–873]	160 [65–2484]	.8
Ongoing BTT	0	1(3)		3
Ongoing time	0	1252		135 [34–233]
Destination therapy (DT)	0	2 (7)		0
Ongoing DT		0
Time on DT		638 [159–1117]

*Significant, p < .05.

**One patient excluded due to mortality in the OR (n = 29).

Tx: Heart transplant.

Table 3. Adverse event rates for HMI and HMII patients*.

	HMI 11 pt-yrs			HMII 26 pt-yrs
Adverse events	n (%)	Events, n	Events/pt-yrs	n (%)	Events, n	Events/pt-yrs	p
Right heart failure	4 (25)	4	0.36	12 (40)	12	0.47	.32
Reoperation bleeding	1 (6)	1	0.09	8 (27)	11	0.43	.10
Pump thrombosis	0	0	–	5 (17)	6	0.23	.09
Major CVI	2 (13)	3	0.27	5 (17)	5	0.19	.51
Thromboembolism	2 (13)	3	0.27	3 (10)	3	0.12	.81
Haemorrhage	0	0	–	2 (7)	2	0.07	.31
Gastrointestinal bleeding	0	0	–	1 (3)	1	0.04	.49
Septicaemia/Infection	9 (56)	9	0.81	12 (40)	14	0.54	.42
Device infection	4 (25)	5	0.45	8 (27)	13	0.50	.91
Temporary dialysis	0	0	–	6 (20)	6	0.23	.06

*HMIII is not listed here due to few events related to these patients.

pt-yrs: patient-years.