Biomarkers of inflammation and coagulation after minimally invasive mitral valve surgery: a prospective comparison to conventional surgery

Figures & data

Table 1. Patient characteristics in minimally invasive surgery group vs conventional technique group.

Characteristic	MIMVS n = 35 (%)	Conventional group n = 36 (%)	p value
Age (years)	56 ± 11	62 ± 12	0.02
Female gender	3 (9)	8 (22)	0.11
Height (cm)	178 ± 8	177 ± 10	0.67
Weight (kg)	76 ± 9	83 ± 16	0.07
Hypertension	11 (32)	17 (47)	0.20
Diabetes	1 (3)	1 (3)	0.98
COPD	0	1 (3)	0.32
Creatinine	80 ± 13	84 ± 16	0.21
Preoperative LVEF 30–50%	2 (6)	2 (6)	1
Preoperative LVEF <30%	0	0
NYHA Class III-IV	6 (17)	1 (3)	0.11
Pulmonary hypertension (>60mmHg)	6 (17)	2 (6)	0.26
Previous AFib	2 (6)	6 (17)	0.15
Peripheral vascular disease	0	0	1
Previous cardiac surgery	0	0	1
EuroScore 2	0.78 ± 0.36	1.11 ± 0.72	0.019
Preoperative Aspirin	0	8 (22)	0.005

Values were expressed as number and percentage (%) or as mean ± standard deviation. ASA: acetyl salicylic acid.

Table 2. Operative characteristics in minimally invasive surgery group vs conventional technique group.

Characteristic	MIMVS n = 35 (%)	Conventional group n = 36 (%)	p value
CPB time (min)	127 [115–146]	79 [65–112]	<0.001
Aortic cross clamp (min)	76 [58–82]	56 [42–90]	0.07
Lowest temperature (°C)	34 [33–36]	36 [35–36]	0.04
Conversion to sternotomy	1 (3)		NA
Mitral valve replacement	0	1 (3	0.43
Post operative MR
None	28 (80)	24 (67)
Trace	6 (17)	8 (22)
Grade 1	0	1 (3)

Values were expressed as number and percentage (%) or as median [IQR]. CPB: cardiopulmonary bypass; MR: mitral regurgitation.

Table 3. Postoperative bleeding/transfusion outcomes in minimally invasive surgery group vs conventional technique group.

Variable	MIMVS n = 35 (%)	Conventional group n = 36 (%)	p value
Bleeding/drain volume (ml)	395 [190–705]	570 [400–1040]	0.04
Revision bleeding	1 (3)	1 (3)	0.98
Any transfusion	5 (14)	12 (35)	0.04
Packed RBC	3 (9)*	8 (24)	0.09
Plasma	1 (3)	6 (17)	0.11
Platelets	3 (9)	7 (19)	0.31

Values were expressed as number and percentage (%), or as median [IQR]. RBC: packed red blood cells.

Figure 1. Inflammatory response MIMVS vs CS.

Figure 2. ROTEM.

Data availability statement

Not possible due to limitations in ethical approval.