Values of three-dimensional speckle tracking imaging for the diagnosis of coronary artery disease

Figures & data

Table 1. Demographic and clinical characteristics of suspected coronary artery disease (CAD) patients who were diagnosed with CAD or without CAD (NCAD) through coronary angiography.

Features	NCAD (n = 118)	CAD (n = 142)	p value
Age (years)	55 ± 9	56 ± 10	0.202
Gender
Male	65 (55%)	85 (60%)	0.452
Female	53 (46%)	57 (40%)
Family history
Yes	5 (4%)	8 (6%)	0.777
No	113 (96%)	134 (94%)
Smoke
Yes	14 (12%)	23 (16%)	0.375
No	104 (88%)	119 (84%)
Diabetes mellitus
Yes	12 (10%)	25 (18%)	0.109
No	106 (90%)	117 (82%)
Hypertension
Yes	26 (22%)	44 (31%)	0.123
No	92 (78%)	98 (69%)
Dyslipidemia
Yes	19 (16%)	37 (26%)	0.069
No	99 (84%)	105 (74%)
ECG (ST-T abnormalities)
Yes	8 (7%)	18 (13%)	0.147
No	110 (93%)	124 (87%)
Body mass index (kg/m^2)	23.92 ± 3.34	24.27 ± 3.85	0.193
Heart rate (b.Pm)	67 ± 9	68 ± 11	0.261
LVEF (%)	56 ± 3	56 ± 3	0.084

The data were presented as mean ± SD or n (percentage). The comparisons of data were done by the Mann-Whitney test or Fisher’s exact test. LVEF: left ventricular ejection fraction; ECG: Electrocardiograph.

Figure 1. Comparisons of parameters of three-dimensional speckle tracking imaging including global longitudinal strain (GLS, a), global area strain (GAS, B), global circumferential strain (GCS, C), and global radial strain (GRS, D) in suspected coronary artery disease (CAD) patients who diagnosed with CAD (n = 142) or without CAD (NCAD, n = 118) through coronary angiography. Data were shown with mean ± SD. ***p < 0.001 from unpaired t-test with Welch’s correction.

Figure 2. ROC analysis for the diagnostic value of three-dimensional speckle tracking imaging in coronary artery disease.

Table 2. Diagnostic values in ROC analysis.

	AUC (95% CI)	Cut off	p value	Sensitivity (%)	Specificity (%)	Youden index
GLS	0.69 (0.63 to 0.76)	−19.11	<0.001	50.70	80.51	0.31
GAS	0.74 (0.68 to 0.80)	−30.59	<0.001	64.79	71.19	0.36
GCS	0.81 (0.76 to 0.86)	−18.34	<0.001	81.69	69.49	0.51
GRS	0.66 (0.59 to 0.73)	40.70	<0.001	59.86	70.34	0.30
Combined	0.89 (0.85 to 0.93)	–	<0.001	79.58	84.75	0.64

AUC: area under the curve; CI: confidence interval.

COMPUTE Combined = 0.18 * GLS + 0.333 * GCS + 0.167 * GAS − 0.085 * GRS.

Figure 3. Comparisons of parameters of three-dimensional speckle tracking imaging including global longitudinal strain (GLS, a), global area strain (GAS, B), global circumferential strain (GCS, C), and global radial strain (GRS, D) among patients with different severity of coronary artery disease. Data were shown with mean ± SD. *p < 0.05, **p < 0.01 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.