http://orcid.org/0000-0001-7781-6305
Figures & data
Figure 1. Innate immunity cytokines in IgG4-related disease. Plasmacytoid dendritic cells (pDCs) produce type I IFN (IFN-α) in response to neutrophil extracellular traps (NETs) and Toll-like receptor (TLR)-nucleotide binding oligomerization domain-like receptor (NLR) ligands. pDCs produce B cell activating factor (BAFF) and IL-33 in an IFN-α-dependent manner. The IFN-α-IL-33 axis in pDCs mediates chronic fibro-inflammatory responses during IgG4-related disease (IgG4-RD). BAFF is also produced by macrophages and basophils in response to TLR-NLR ligands. BAFF induces IgG4 production by B cells. IgG4 antibody plays anti-inflammatory roles rather than pro-inflammatory roles in IgG4-RD.
