Mechanisms of blood pressure reduction with sodium-glucose co-transporter 2 (SGLT2) inhibitors

Figures & data

Table 1. Possible interrelated mechanisms of blood pressure (BP) reduction with sodium-glucose co-transporter 2 inhibitors.

Volume depletion due to diuresis and natriuresis Loop-diuretic-like action leading to conversion of salt-sensitive profile of BP to a non-salt-sensitive one Weight loss Improvement of arterial stiffness Uric acid reduction Inhibition of sympathetic nervous system activity