Addressing high dose AAV toxicity – ‘one and done’ or ‘slower and lower’?

Figures & data

Figure 1. An estimate of the number of cells in the human body compared to the number of full viral particles in a high vector dose of AAV.

Estimated number of total cells, neurons, hepatocytes, and skeletal muscle fibers in the human body [36] and the number of full viral capsids in a   1E14 vg/kg dose of AAV for a 70 kg human. Image credits: Male anatomy and male back muscles by Sebastian Kaulitzki/Science Photo Library via Getty Images; Human brain by Comotion Design via Getty Images; and Human liver by Ingram Publishing via Getty Images.

Bianconi E, Piovesan A, Facchin F, et al. An estimation of the number of cells in the human body. Ann Hum Biol. 2013Nov-Dec;40(6):463–471. PubMed PMID: 23829164.

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