Figures & data
Figure 1. Pak1 over expression promotes proliferation, metastasis and drug resistance in pancreatic cancer through Pak1-NF-κBp65-Fibronectin pathway. Activation of this nexus would enhance tumorigenesis process by activating EMT, fibronectin production, fibrosis, desmoplastic reaction, increasing vascular formation and recruiting immune cells for tumor growth. Blocking of Pak1 activation and downstream nexus pathways with Pak1 inhibitors might play a therapeutic role for the treatment of pancreatic cancer.
