Figures & data
Figure 1. Interplay betweenEMT decision making circuit, PSFs and stemness: Mutually exclusive inhibitory loops including miR200 family/Zeb; miR-34 family/Snail; LIN28/let-7 bring about bistable switch between epithelial (E) and mesenchymal (M) phenotypes, control EMT/MET and stemness. Phenotypic stability factors (PSFs) like OVOL and GRHL2 couple to core-EMT decision making circuits and stabilize hybrid E/M phenotype. NF-κB controls LIN28/let-7 regulation, elevates the likelihood of hybrid E/M phenotype and shifts the stemness window on EMT axis. Solid arrows represent the activation; solid lines represent the repression and circular loops represent the self-activation.
