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Expert Opinion on Therapeutic Targets Volume 24, 2020 - Issue 12
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Editorial

Tuft cells: an emerging therapeutic target for pancreatitis and pancreatic cancer?

Yuning Yanga Fujian University of Traditional Chinese Medicine, Academy of Integrative Medicine, Fuzhou, Fujian, CN 350122;b Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fuzhou, Fujian, CN 350122Correspondence[email protected]
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Ling Dinga Fujian University of Traditional Chinese Medicine, Academy of Integrative Medicine, Fuzhou, Fujian, CN 350122;b Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fuzhou, Fujian, CN 350122Correspondence[email protected]
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Zhiyun Caoa Fujian University of Traditional Chinese Medicine, Academy of Integrative Medicine, Fuzhou, Fujian, CN 350122;c The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 73104View further author information
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Dongfeng Quc The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA 73104View further author information
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Nathaniel Weyganta Fujian University of Traditional Chinese Medicine, Academy of Integrative Medicine, Fuzhou, Fujian, CN 350122;b Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fuzhou, Fujian, CN 350122ORCID Iconhttps://orcid.org/0000-0001-7861-6532View further author information
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Pages 1183-1186 | Received 23 Jul 2020, Accepted 20 Oct 2020, Published online: 12 Nov 2020

Figures & data

Figure 1. Relationship of Tuft Cells, ADM, PanIN formation, and PDAC. Tuft cells are expanded during KRAS-associated ADM, serve an immunomodulatory role with implications for PanIN development and fibrosis via cytokine signaling, and generally disappear with advanced disease

Figure adapted in part based on Liou etal., 2017, Cell Reports 19, 1322–1333 (doi: 10.1016/j.celrep.2017.04.052) and Zhang etal., 2018 Gastroenterology 155(1): 210–223.e3 (doi: 10.1053/j.gastro.2018.03.041)
Figure 1. Relationship of Tuft Cells, ADM, PanIN formation, and PDAC. Tuft cells are expanded during KRAS-associated ADM, serve an immunomodulatory role with implications for PanIN development and fibrosis via cytokine signaling, and generally disappear with advanced disease

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