ABSTRACT
Objective
Nuclear paraspeckle assembly transcript 1 (NEAT1), a newly found lncRNA, is found abnormally expressed in digestive system tumors. This meta-analysis aims to evaluate the effect of NEAT1 on digestive system tumors.
Methods
An analysis was conducted to investigate NEAT1 expression in digestive system tumors from the PubMed, Embase, and Web of Science databases. The relationship between NEAT1 expression and patient overall survival (OS) and clinicopathology was evaluated by correlation analysis with the pooled hazard ratio (HR), 95% confidence interval (CI), and odds ratio (OR).
Results
A total of 12 published studies were enrolled in this meta-analysis. The NEAT1 overexpression was significantly associated with poor OS (HR = 1.64, 95% CI:1.41–1.91, p < 0.05), lymphatic metastasis (OR = 2.70, 95% CI: 2.02–3.61, p < 0.05), distal metastasis (OR = 3.01, 95% CI: 1.97–4.59, p < 0.05) and advanced tumor stage (OR = 3.04, 95% CI: 2.32–3.99, p < 0.05). However, digestive system tumor patients with high NEAT1 expression was not related to the patients’ age (OR = 0.91, 95% CI: 0.65–1.26, p = 0.561), gender (OR = 1.04, 95% CI: 0.81–1.33, p = 0.761), tumor size (OR = 1.84, 95% CI: 0.88–3.88, p = 0.106), and tumor differentiation (OR = 0.86, 95% CI: 0.51–1.44, p = 0.570).
Conclusion
Collectively, NEAT1 can be used as a potential biomarker to predict the prognosis of patients with digestive system tumors, which is worth verifying in clinical practice.
Abbreviations
NEAT1 | = | Nuclear paraspeckle assembly transcript 1 |
OS | = | Overall survival |
CI | = | Confidence interval |
OR | = | Odds ratio |
HR | = | Hazard ratio |
EC | = | Esophageal cancer |
lncRNA | = | Long non-coding RNA |
PRISMA | = | Preferred Reporting Items For Systematic Review |
NOS | = | Newcastle–Ottawa Scale |
PanINs | = | Pancreatic intraepithelial neoplasia |
IPMNs | = | Lesions similar to intraductal papillary mucinous tumor |
HCC | = | Hepatocellular carcinoma |
Disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Availability of data and materials
All data generated or analyzed in this study are included in this published article.