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Expert Review of Molecular Diagnostics Volume 23, 2023 - Issue 10
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Key Paper Evaluation

Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer

Bhavik Y. Patela Section of Oncology, Dept. of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK;b Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK;c Department of Hepato-Pancreato-Biliary (HPB) Surgery, Royal Surrey County Hospital, Guildford, UKView further author information
,
Rahul Bhomed Cancer Sciences, University of Southampton, Southampton, UKView further author information
,
Daniel S. K. Liue Division of Cancer, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UKView further author information
,
Elisa Giovannettif Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands;g Cancer Pharmacology Lab, Fondazione Pisana per La Scienza, San Giuliano, ItalyView further author information
,
Nabeel Meralia Section of Oncology, Dept. of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK;b Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK;c Department of Hepato-Pancreato-Biliary (HPB) Surgery, Royal Surrey County Hospital, Guildford, UKView further author information
,
John N. Primroseh Department of Surgery, University of Southampton, Southampton, UKView further author information
,
Alex H. Mirnezamih Department of Surgery, University of Southampton, Southampton, UKView further author information
,
Timothy A. Rockallb Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UKView further author information
,
Nicola Annelsa Section of Oncology, Dept. of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UKView further author information
&
Adam E. Framptona Section of Oncology, Dept. of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK;b Minimal Access Therapy Training Unit (MATTU), Leggett Building, University of Surrey, Guildford, UK;c Department of Hepato-Pancreato-Biliary (HPB) Surgery, Royal Surrey County Hospital, Guildford, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1392-2755View further author information
ORCID Icon show all
Pages 843-849 | Received 03 Jan 2023, Accepted 08 Aug 2023, Published online: 21 Aug 2023

Figures & data

Figure 1. A schematic overview of an extracellular vesicle (EV), demonstrating a typical lipid bilayer vesicle with some examples of associated transmembrane proteins, receptors, and associated cargo including miRNAs. (created with BioRender).

Figure 1. A schematic overview of an extracellular vesicle (EV), demonstrating a typical lipid bilayer vesicle with some examples of associated transmembrane proteins, receptors, and associated cargo including miRNAs. (created with BioRender).

Figure 2. A diagrammatic representation of the effects of miR-181a-5p from CRC EVs on HSCs and the resulting effects on further miRNA transcription and the tumor microenvironment. (created with BioRender).

Figure 2. A diagrammatic representation of the effects of miR-181a-5p from CRC EVs on HSCs and the resulting effects on further miRNA transcription and the tumor microenvironment. (created with BioRender).

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