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Original Research

Impact on hospitalizations of long-term versus short-term therapy with sodium zirconium cyclosilicate during routine outpatient care of patients with hyperkalemia: the recognize I study

, , , ORCID Icon, , , & show all
Pages 241-250 | Received 17 Jun 2022, Accepted 19 Dec 2022, Published online: 28 Dec 2022

Figures & data

Figure 1. Diagram of patient flow in the RECOGNIZE I study.

SZC: sodium zirconium cyclosilicate
Figure 1. Diagram of patient flow in the RECOGNIZE I study.

Table 1. Baseline demographics and clinical characteristics according to duration of SZC therapy in the total patient population and in the subgroup of patients without end-stage kidney disease.

Table 2. Healthcare resource utilization during follow-up according to duration of SZC therapy in the total patient population and in the subgroup of patients without end-stage kidney disease.

Figure 2. Proportion of patients with (a) inpatient hospitalization and (b) emergency department visits during follow-up according to the duration of SZC therapy, in the total population and in the subgroup of patients without end-stage kidney disease.

*P < 0.05 vs. short-term therapy (Chi-square test used for comparison; unadjusted analysis).
ED: emergency department; ESKD: end-stage kidney disease; SZC: sodium zirconium cyclosilicate.
Figure 2. Proportion of patients with (a) inpatient hospitalization and (b) emergency department visits during follow-up according to the duration of SZC therapy, in the total population and in the subgroup of patients without end-stage kidney disease.

Figure 3. Regression model of predictors of long-term (>90 days) versus short-term (≤90 days) SZC therapy in (a) the total patient population and (b) patients without end-stage kidney disease.

aBold text indicates significant values.
AKI: acute kidney injury; CI: confidence interval; CKD: chronic kidney disease; ED: emergency department; ESKD: end-stage kidney disease; HF: heart failure; HRU: healthcare resource utilization; RAASi: renin–angiotensin–aldosterone system inhibitor; SPS: sodium polystyrene sulfonate; SZC: sodium zirconium cyclosilicate
Figure 3. Regression model of predictors of long-term (>90 days) versus short-term (≤90 days) SZC therapy in (a) the total patient population and (b) patients without end-stage kidney disease.

Table 3. Proportion of patients with hyperkalemia-related and all-cause healthcare resource utilization during follow-up according to duration of SZC therapy.

Supplemental material

Supplemental Material

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