A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats

Figures & data

Figure 1 Structures of tested oximes.

Table I.  Rate of reactivation of tabun-inhibited AChE by oximes in rat blood and brain in vivo.

	AChE activity (μkat/L or μkat/kg)
Treatment	Blood	Brain
Atropine	4.55 ± 1.19	11.63 ± 1.27
Atropine + obidoxime	7.14 ± 0.66	9.25 ± 1.54
(% reactivation)	(24.3*)	(0)
Atropine + HI-6	3.95 ± 0.39	12.40 ± 0.71
(% reactivation)	(0)	(6.7)
Atropine + K074	6.56 ± 1.04	21.60 ± 3.03
(% reactivation)	(18.8*)	(86.8*)
Atropine + K075	6.64 ± 0.75	13.22 ± 0.95
(% reactivation)	(19.6*)	(13.9)

*Significantly different from atropine-treated group at the level of P < 0.05. The untreated control value for rat blood AChE was 15.20 μkat/L and for brain AChE activity 23.11 μkat/kg.

Table II.  Rate of reactivation of cyclosarin-inhibited AChE by oximes in rat blood and brain in vivo.

	AChE activity (μkat/L or μkat/kg)
Treatment	Blood	Brain
Atropine	3.72 ± 0.66	24.23 ± 3.77
Atropine + obidoxime	3.90 ± 0.29	31.99 ± 3.00
(% reactivation)	(2.8)	(35.5*)
Atropine + HI-6	8.46 ± 0.88	36.10 ± 6.83
(% reactivation)	(72.0*)	(49.8*)
Atropine + K074	3.90 ± 0.31	33.39 ± 3.07
(% reactivation)	(2.8)	(42.0*)
Atropine + K075	5.60 ± 0.61	32.29 ± 4.58
(% reactivation)	(28.7*)	(36.9*)

*Significantly different from atropine-treated group at the level of P < 0.05. The untreated control value for rat blood AChE was 10.30 μkat/L and for brain AChE activity 46.05 μkat/kg.