Figure 1 PDE4 inhibitors.
Figure 2 Synthesis of pyrrolo[2,3-d]pyridazinones 9a–e.
![Figure 2 Synthesis of pyrrolo[2,3-d]pyridazinones 9a–e.](/cms/asset/4bca8175-2350-4af4-bfd3-f243648ecb2a/ienz_a_211405_f0002_b.gif)
Figure 3 Synthesis of pyrrolo[2,3-d]pyridazinones 15a–f.
![Figure 3 Synthesis of pyrrolo[2,3-d]pyridazinones 15a–f.](/cms/asset/94f387e9-0b31-4048-8306-3be4e3a07680/ienz_a_211405_f0003_b.gif)
Table I. Effects of compounds 9 and 15 on PDE4 isoenzymes, PDE3 and displacement of [3H]Rolipram from its binding site (HARBS).
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Table II. TNFα inhibition values for compounds 8, 15a and 15f.
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