Synthesis of N-substituted indole-2-carboxamides and investigation of their biochemical responses against free radicals

Figures & data

Figure 1 Chemical structures of some active antioxidants.

Scheme 1 Synthesis of compounds 1-10.

Table I.  Inhibitory effects of compounds 1–10 on superoxide anion production and LP.

Comp.	Concentration in the incubation medium	% Inhibition of superoxide anion^a	% Inhibition of LP^a
1	10^− 3	NA	48 ± 1.4
	10^− 4	NA	NA
2	10^− 3	NA	14 ± 2.1
	10^− 4	NA	NA
3	10^− 3	97 ± 2.0	46 ± 3.2
	10^− 4	NA	NA
4	10^− 3	98 ± 1.0	6 ± 1.4
	10^− 4	22 ± 2.0	NA
5	10^− 3	57 ± 4.0	41 ± 1.8
	10^− 4	NA	NA
6	10^− 3	80 ± 4.0	43 ± 1.4
	10^− 4	NA	NA
7	10^− 3	49 ± 5.0	50 ± 3.2
	10^− 4	NA	29 ± 2.4
8	10^− 3	70 ± 3.0	45 ± 2.8
	10^− 4	NA	29 ± 1.0
9	10^− 3	80 ± 4.0	12 ± 1.4
	10^− 4	19 ± 3.0	NA
10	10^− 3	15 ± 3.0	67 ± 3.0
	10^− 4	NA	70 ± 4.0
Vit E	10^− 3	83 ± 6.0	95 ± 3.2
	10^− 4	10 ± 2.0	93 ± 1.8

NA, not active.

^a Each value represents the mean ± S.D. of 2–4 independent experiments.

Figure 2 Percentage inhibition by compounds of liver LP level and liver superoxide anion production at 10^{− 3}M concentration.