Figures & data
Figure 1 Double reciprocal Lineweaver–Burk plots for kinetics of 0.94 nM ADA at pH = 7.5 in the presence of 0.0 (▪), 7.5? (▪), 15.0 (▴), 22.5 (▵) and 30.0 μM (() of (a) aspirin at 27°C and (b) diclofenac at 37°C. Inset of each figure (secondary plots): apparent Michaelis constant, K'm (Km,app) versus concentration of inhibitor, [I].
![Figure 1 Double reciprocal Lineweaver–Burk plots for kinetics of 0.94 nM ADA at pH = 7.5 in the presence of 0.0 (▪), 7.5? (▪), 15.0 (▴), 22.5 (▵) and 30.0 μM (() of (a) aspirin at 27°C and (b) diclofenac at 37°C. Inset of each figure (secondary plots): apparent Michaelis constant, K'm (Km,app) versus concentration of inhibitor, [I].](/cms/asset/c8c197a4-c134-4fe4-b944-16b9bba7a54c/ienz_a_222827_f0001_b.gif)
Figure 2 ΔHo versus KI for first 10 injections, according to Equation (2) for (a) aspirin (b) diclofenac. The coordinates of intersection point of curves give true values for ΔHo and KI.
![Figure 2 ΔHo versus KI for first 10 injections, according to Equation (2) for (a) aspirin (b) diclofenac. The coordinates of intersection point of curves give true values for ΔHo and KI.](/cms/asset/943164cb-20b5-448b-9215-30752da2894c/ienz_a_222827_f0002_b.gif)
Table I. List of descriptors used in this work.
Table II. Values of descriptors was calculated by Hyperchem-7.0 and Dragon-3.0.
Table II. continued.
Figure 3 The linear correlation between the experimental values of logKI and the related values of the prediction set by MLR analysis on descriptors.
![Figure 3 The linear correlation between the experimental values of logKI and the related values of the prediction set by MLR analysis on descriptors.](/cms/asset/a00d6828-1ea0-4073-99eb-efa6d9aa30d6/ienz_a_222827_f0004_b.gif)
Table III. Rotated component matrix for studied descriptors.
Table IV. Specification of the multiple linear regression model for factors.