Synthesis and anticandidal activity of some imidazopyridine derivatives

Figures & data

Scheme 1 The general synthetic reaction.

Table I.  Some characteristics of the compounds.

Comp.	R	M.P. (°C)	Yield (%)	Molecular Formula
2a	H	240–242	80	C18H16N6O4
2b	Cl	275–277	76	C18H15ClN6O4
2c	Br	279–281	86	C18H15BrN6O4
2d	F	265–267	79	C18H15FN6O4
2e	CH3	260–261	75	C19H18N6O4
2f	OCH3	258–259	84	C19H18N6O5
2g	NO2	270–272	70	C18H15N7O6
2h	N(CH3)2	247–248	71	C20H21N7O4

Table II.  Antifungal activities of the compounds (mg/mL).

Comp.	A	B	C	D	E	F	G	H
2a	0.25	0.5	0.125	0.25	0.25	0.5	0.5	0.25
2b	0.25	0.25	0.5	0.5	0.25	0.25	0.25	0.25
2c	0.125	0.25	0.25	0.125	0.125	0.25	0.5	0.5
2d	0.5	0.5	0.25	0.125	0.25	0.5	0.5	0.25
2e	0.125	0.125	0.25	0.25	0.125	0.5	0.5	0.125
2f	0.5	0.5	0.5	0.5	0.125	0.25	0.25	0.25
2g	0.5	0.25	0.125	0.125	0.25	0.25	0.25	0.25
2h	0.5	0.25	0.125	0.25	0.25	0.5	0.25	0.125
Reference	0.0625	0.0625	0.125	0.0312	0.0078	0.0312	0.25	0.0156

Reference: Ketoconazole, A: Candida albicans (isolates obtained from Osmangazi University, Faculty of Medicine, Eskisehir, Turkey), B: Candida albicans (ATCC 90028), C: Candida glabrata (isolates obtained from Osmangazi University, Faculty of Medicine, Eskisehir, Turkey), D: Candida utilis (NRLL Y-900), E: Candida tropicalis (NRLL Y-12968), F: Candida krusei (NRLL Y-7179), G: Candida zeylanoides (NRLL Y-1774), and H: Candida parapsilosis (NRLL Y-12696).