New antibacterial pentacyclic triterpenes from Myricaria elegans Royle. (tamariscineae)

Figures & data

Table I.  ¹³C–NMR data of compound 1 and compound 2 (CDCl₃).

	1		2
Position	δC	multiplicity	δC	multiplicity
1	80.2	CH	139.6	CH
2	69.5	CH	127.0	CH
3	80.8	CH	72.2	CH
4	38.2	C	37.8	C
5	53.4	CH	48.0	CH
6	67.4	CH	18.2	CH2
7	40.7	CH2	39.3	CH2
8	41.5	C	36.7	C
9	45.5	CH	47.7	CH
10	40.6	C	35.4	C
11	24.8	CH2	26.0	CH2
12	124.7	CH	117.1	CH
13	142.9	C	139.1	C
14	41.5	C	41.5	C
15	27.8	CH2	22.0	CH2
16	31.9	CH2	33.9	CH2
17	48.6	C	47.6	C
18	48.7	CH	54.7	CH
19	36.2	CH	37.3	CH
20	56.4	CH	39.5	CH
21	132.1	CH	30.3	CH2
22	134.2	CH	36.4	CH2
23	21.8	CH3	64.7	CH3
24	25.4	CH3	18.7	CH3
25	15.6	CH3	19.6	CH3
26	17.8	CH3	17.5	CH3
27	24.1	CH3	23.8	CH3
28	18.2	CH3	17.9	CH3
29	17.8	CH3	16.8	CH3
30	179.1	C	181.5	C

^aAssignments confirmed by decoupling, H/H COSY, NOESY, HMQC, and HMBC spectra. J values are given in Hz.

Table II.  Antibacterial activities of compounds 1–6. Relative to the standard drug imipenem.

Compound	EC	BS	SF	SA	PA	ST
Imipenem	30	33	27	33	24	25
1	–	15	12	24	–	15
2	10	15	10	22	13	17
3	11	16	15	15	17	17
4	–	12	–	15	16	18
5	–	15	15	–	17	17
6	–	14	13	–	18	20

For details, see Exper. Part. Inhibition zones are given in mm. Abbreviations: EC, Escherichia coli; BS, Bacillus subtilis; SF, Shigella flexneri; SA, Staphylococcus aureus; PA, Pseudomonas aeruginosa; ST, Salmonella typhi.