Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 24, 2009 - Issue 1
Submit an article Journal homepage
840
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Synthesis and characterization of some new 2(3H)-benzoxazolones with analgesic and antiinflammatory activities

Nesrin Gökhan-Kelekçi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye, Ankara, TurkeyCorrespondence[email protected]
,
Meriç Köksal Faculty of Pharmacy, Yeditepe University, 34755 Kayişdağı, Istanbul, Turkey
,
Songül Ünüvar Department of Pharmacology, Faculty of Pharmacy, Inönü University, 44280 Malatya, Turkey
,
Göknur Aktay Department of Pharmacology, Faculty of Pharmacy, Inönü University, 44280 Malatya, Turkey
&
Hakki Erdoğan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye, Ankara, Turkey
Pages 29-37 | Received 27 Jul 2007, Accepted 08 Nov 2007, Published online: 20 Oct 2008

Figures & data

Scheme 1.  Protocol for synthesis of titled compounds 3a–3h, 4a–4d.

Scheme 1.  Protocol for synthesis of titled compounds 3a–3h, 4a–4d.

Scheme 2.  Fragmentation pattern of the titled compounds 3a–3h, 4a–4d.

Scheme 2.  Fragmentation pattern of the titled compounds 3a–3h, 4a–4d.

Table I.  Analgesic/anti-inflammatory activities for compounds 3a–3h, 4a–4d.

Figure 1.  Effect of compounds against carrageenan-induced hind paw edema model at 50 mg/kg dose.

Figure 1.  Effect of compounds against carrageenan-induced hind paw edema model at 50 mg/kg dose.

Figure 2.  Effect of compounds against carrageenan-induced hind paw edema model at 100 mg/kg dose.

Figure 2.  Effect of compounds against carrageenan-induced hind paw edema model at 100 mg/kg dose.

Figure 3.  Effect of compounds against carrageenan-induced hind paw edema model at 200 mg/kg dose.

Figure 3.  Effect of compounds against carrageenan-induced hind paw edema model at 200 mg/kg dose.

Figure 4.  Analgesic effect of active compounds on acetic acid induced abdominal writhing and hot plate test.

Figure 4.  Analgesic effect of active compounds on acetic acid induced abdominal writhing and hot plate test.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

Antiinflammatory actions of ephedrines in acute inflammations.
Source: Georg Thieme Verlag KG
Risk of cardiovascular events and rofecoxib: cumulative meta-analysis
Source: Elsevier BV
Synthesis, Analgesic and Antiinflammatory Properties of Certain 5-/6-Acyl-3-(4-substituted-1-piperazinylmethyl)-2-benzoxazolinones Derivatives.
Source: Wiley
Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives
Source: FapUNIFESP (SciELO)
Analgesic and antiinflammatory activity screening of 6-acyl-3-piperazinomethyl-2-benzoxazolinone derivatives
Source: Elsevier BV
Cyclooxygenase inhibitors – current status and future prospects
Source: Elsevier BV
Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzothiazol-2-one 7-ethylamines.
Source: American Chemical Society (ACS)
The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor
Source: Elsevier BV
Synthesis of 3-(4-substituted benzoylmethyl)-2-benzoxazolinones and screening antimicrobial activities.
Source: Elsevier BV
Nonsteroidal cardiotonics. 2. The inotropic activity of linear, tricyclic 5-6-5 fused heterocycles.
Source: American Chemical Society (ACS)
Amide Derivatives of [5-Chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic Acids as Potential Analgesic and Antiinflammatory Compounds.
Source: Wiley
Acute and long term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in tests of nociception in mice.
Source: Wiley
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
Source: American Chemical Society (ACS)
Amino ketone and amino alcohol derivatives of benzoxazolinone: synthesis, adrenergic and antihypertensive properties
Source: Elsevier BV

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.