In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum

Figures & data

Figure 1.  Structures of 11(13)-dehydroivaxillin (DDV) isolated from Carpesium ceruum.

Table I.  Blood schizontocidal activity of 11(13)-dehydroivaxillin (DDV) treated Plasmodium berghei infection in mice.

		Four-day test		Repository activity
Compound/Drug	Dose (mg/kg/day)	Average % parasitaemia	Average % suppression	Average % parasitaemia	Average % suppression
DDV^b	2	23.3 ± 0.32*	58.6	21.4 ± 0.32*	61.9
	5	12.4 ± 0.18*	77.9	16.3 ± 0.18*	71.0
	10	6.9 ± 0.23*	87.7	7.2 ± 0.21*	87.2
Chloroquine	5	6.2 ± 0.15*	91.2	–
Pyrimethamine	1.2	–	–	4.6 ± 0.21*	91.8
Control (D.W.^a)	0.2mL	56.3 ± 0.16	–	4.6 ± 0.21*	–

*Data are expressed as mean ± for five animals per group when compared with control. P < 0.05. ^aD.W.: Distilled water. ^bDDV: 11(13)-dehydroivaxillin

Figure 2.  Effect of 11(13)-dehydroivaxillin (DDV) on established infection.