Protein glycation inhibitory activities of Lawsonia inermis and its active principles

Figures & data

Table I.  In vitro quantitative inhibition of glycation by compounds 1, 2 and an alcoholic extract of Lawsonia inermis.

COMPOUND NAME	FLURECENCE (FU)	% INHIBITION	CONCENTRATION (μM/ml) (μg/ml)	IC50 VALUE
Lawsonia inermis alcoholic extract	195 FU	77.95	1500 μg	82.06 ± 0.13
	226 FU	74.28	1000 μg
	288 FU	67.32	500 μg
	296 FU	66.62	250 μg
	328 FU	62.62	100 μg
	611 FU	36.67	31.25 μg
Gallic acid (2)	338 FU	66.98	1000 μM	401.7 ± 6.23
	383 FU	58.83	500 μM
	535 FU	36.51	250 μM
	625 FU	34.88	100 μM
	629 FU	30.62	62.5 μM
	681 FU	26.87	31.25 μM
	176 FU	79.1	1000 μM
Lawsone (1)	228 FU	72.9	500 μM	67.42 ± 1.46
	213 FU	74.7	250 μM
	236 FU	72	100 μM
	530 FU	37.25	50 μM
	594 FU	29.6	31.25 μM
STANDARD (1 mM/mL)
RUTIN	127 FU	85.80%	100 μM	41.9 ± 2.3 μM

Figure 1.  Glycation inhibition activity of Lawsonia inermis.

Figure 2.  Glycation inhibition activity of gallic acid.

Figure 3.  Glycation inhibition activity of 2-hydroxy-1,4-naphthoquinone.