PAMAM dendrimers for the delivery of the antibacterial Triclosan

Figures & data

Figure 1 Structure of Triclosan (1).

Figure 2 Chromatogram of TCN with naphthalene internal standard.

Figure 3 The effect of G3 PAMAM dendrimer concentration on TCN solubility.

Figure 4 The solubility of TCN at a range of pH values, with (▪) and without (▴) 3 mM G3 dendrimer.

Scheme 1 Conjugation of phenylalanine to G0-PAMAM dendrimer.

Figure 5 Partial structure of dendrimer branch showing peak labels for ¹H NMR spectra of PAMAM dendrimer conjugates.

Scheme 2 Synthesis of G3 PAMAM Phenylalanine dendrimers. The number of conjugated branches in compounds (7) and (8) [32 for fully conjugated, 21 or 16 for partially conjugated] depends on the number of equivalents of (3) added in the conjugation step.