Figures & data
Table I. Inhibitory effects of umbelliferone aminoalkyl derivatives on sterol biosynthesis in 3T3 fibroblasts incubated with radiolabeled acetate.
Table II. Inhibitory effects of umbelliferone aminoalkyl derivatives on sterol biosynthesis in human keratinocytes incubated with radiolabeled acetate.
Table III. Effect of temperature, pH and detergent concentration on the activity of human OSC expressed in yeast.
Table IV. Effect of umbelliferone aminoalkyl derivatives on the activity of human OSC expressed in yeast.
Figure 3. OSC residues interacting with the compound 2. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.
![Figure 3. OSC residues interacting with the compound 2. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.](/cms/asset/56deca6e-b39b-45a3-897e-3ce3c29fd929/ienz_a_332035_f0003_b.gif)
Figure 4. OSC residues interacting with the compound 1. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.
![Figure 4. OSC residues interacting with the compound 1. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.](/cms/asset/6496ac9a-7218-4fac-80e4-b04a98dca16f/ienz_a_332035_f0004_b.gif)
Figure 5. OSC residues interacting with the compound 3. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.
![Figure 5. OSC residues interacting with the compound 3. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.](/cms/asset/aac65983-3b02-4908-be24-6f9112da7d56/ienz_a_332035_f0005_b.gif)
Figure 6. OSC residues interacting with the compound 4. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.
![Figure 6. OSC residues interacting with the compound 4. (in sticks) in the docking model. For comparison, the reference inhibitor Ro 48-8071 in the minimized model, as derived from X-ray [Citation7], is also reported.](/cms/asset/58b03b0b-df0e-4b7e-b43e-79711e085343/ienz_a_332035_f0006_b.gif)