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Research Article

Biologically active macrocyclic complexes derived from diaminonaphthalene and glyoxal: Template synthesis and spectroscopic approach

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Pages 795-803 | Received 15 Mar 2008, Accepted 03 Jun 2008, Published online: 01 Jun 2009

Figures & data

Table I. Analytical data of divalent cobalt, nickel, copper, zinc and cadmium complexes derived from glyoxal and, 8-diaminonaphthalene.

Figure 1. 1H NMR spectrum of [Zn(C24H16N4)(OAc)2] complex.

Figure 1.  1H NMR spectrum of [Zn(C24H16N4)(OAc)2] complex.

Figure 2. FAB mass spectra of [Co(C24H16N4)(NO3)2] complex.

Figure 2.  FAB mass spectra of [Co(C24H16N4)(NO3)2] complex.

Figure 3. Structure of the complexes. Where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II); X = Cl− 1, NO3− 1, CH3COO− 1.

Figure 3.  Structure of the complexes. Where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II); X = Cl− 1, NO3− 1, CH3COO− 1.

Table II. Minimum inhibitory concentration (MIC) of the complexes against test bacteria by using agar dilution assay.

Figure 4. Comparison of MIC of compounds with standard antibiotics up to the concentration 16 μg/mL. Bs—Bacillus subtilis (MTCC 8509); Bst—Bacillus stearothermophilus (MTCC 8508); Pp—Pseudomonas putida (MTCC 121); Ec—Escherichia coli (MTCC 51); Chloramphenicol, Streptomycin—standard antibiotics.

Figure 4.  Comparison of MIC of compounds with standard antibiotics up to the concentration 16 μg/mL. Bs—Bacillus subtilis (MTCC 8509); Bst—Bacillus stearothermophilus (MTCC 8508); Pp—Pseudomonas putida (MTCC 121); Ec—Escherichia coli (MTCC 51); Chloramphenicol, Streptomycin—standard antibiotics.

Table III. Antifungal (percentage inhibition) activities of the complexes against the fungal strains. (for concentration—100 μg/mL).

Figure 5. Comparison of the percentage inhibition of compounds with standard drug Cyclohexamide against fungal strains. AF—Aspergillus flavus; AN—Aspergillus niger; Cyclohexamide—standard drug.

Figure 5.  Comparison of the percentage inhibition of compounds with standard drug Cyclohexamide against fungal strains. AF—Aspergillus flavus; AN—Aspergillus niger; Cyclohexamide—standard drug.

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