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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 24, 2009 - Issue 3
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Research Article

A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease

Rosa TundisDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), ItalyCorrespondence[email protected]
,
Federica MenichiniDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), Italy
,
Filomena ConfortiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), Italy
,
Monica R. LoizzoDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), Italy
,
Marco BonesiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), Italy
,
Giancarlo StattiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), Italy
&
Francesco MenichiniDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Nutritional and Health Sciences, University of Calabria, I-87030, Rende (CS), Italy
 show all
Pages 818-824 | Received 07 May 2008, Accepted 07 Jul 2008, Published online: 01 Jun 2009

Figures & data

Table I.  MS data of tetrahydroisoquinoline alkaloids in Salsola species.

Table II.  Tetrahydroisoquinoline alkaloids content of Salsola species.

Figure 1.  Structures of identified alkaloids.

Figure 1.  Structures of identified alkaloids.

Figure 2.  Dose-dependent antiradical activity of Salsola species alkaloid extracts. Each data represent the mean ± S.D. (n = 3).

Figure 2.  Dose-dependent antiradical activity of Salsola species alkaloid extracts. Each data represent the mean ± S.D. (n = 3).

Table III.  Antiradical activity of Salsola species alkaloid extracts.

Figure 3.  Dose-dependent inhibition of (a) acetylcholinesterase and (b) butyrylcholinesterase by Salsola species alkaloid extracts. Each data represent the mean ± S.D. (n = 3).

Figure 3.  Dose-dependent inhibition of (a) acetylcholinesterase and (b) butyrylcholinesterase by Salsola species alkaloid extracts. Each data represent the mean ± S.D. (n = 3).

Table IV.  Acetylcholinesterase and butyrylcholinesterase inhibitory activities of Salsola species alkaloid extracts.

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