Antibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal

Figures & data

Table I.  Analytical data of trivalent chromium, manganese and iron complexes derived from oxalyldihydrazide and glyoxal.

		Found (calcd.) %
Sr. No.	Complexes	M	C	H	N	Colour	Mol. Wt.
1	[Cr(C8H8O4N8)Cl]Cl2	11.65 (11.84)	21.67 (21.86)	1.80 (1.82)	25.47 (25.51)	Yellowish Green	439
2	[Cr(C8H8O4N8)(NO3)](NO3)2	9.89 (10.03)	18.44 (18.53)	1.32 (1.54)	29.51 (29.72)	Yellowish Brown	518
3	[Cr(C8H8O4N8)(OAc)](OAc)2	10.13 (10.21)	32.87 (33.00)	3.14 (3.33)	21.92 (22.00)	Yellowish Brown	509
4	[Mn(C8H8O4N8)Cl]Cl2	12.32 (12.44)	21.56 (21.71)	1.69 (1.80)	25.21 (25.33)	Brown	442
5	[Mn(C8H8O4N8)(OAc)](OAc)2	10.59 (10.74)	32.37 (32.81)	3.08 (3.32)	21.82 (21.87)	Brown	512
6	[Fe(C8H8O4N8)Cl]Cl2	12.50 (12.64)	21.62 (21.67)	1.71 (1.80)	25.14 (25.28)	Yellowish brown	443
7	[Fe(C8H8O4N8)(NO3)](NO3)2	10.67 (10.72)	18.22 (18.39)	1.43 (1.53)	29.41 (29.50)	Light Brown	522
8	[Fe(C8H8O4N8)(OAc)](OAc)2	10.78 (10.91)	32.56 (32.74)	3.17 (3.31)	21.59 (21.83)	Light Brown	513

Figure 1.  Structure of the metal complexes.

Table II.  Minimum inhibitory concentration (MIC) shown by trivalent chromium and iron complexes derived from oxalyldihydrazide and glyoxal against test bacteria.

		MIC (μg/mL)
Sr. No.	Complexes	Bc	Sa	Ec	St
(1)	[Cr(C8H8O4N8)Cl]Cl2	64	128	64	128
(2)	[Cr(C8H8O4N8)NO3](NO3)2	128	>128	64	32
(3)	[Cr(C8H8O4N8)(OAc)](OAc)2	32	64	16	32
(4)	[Fe(C8H8O4N8)Cl]Cl2	64	32	>128	128
(5)	[Fe(C8H8O4N8)(NO3)](NO3)2	>128	64	16	64
(6)	[Fe(C8H8O4N8)(OAc)](OAc)2	8	128	>128	32
	Linezolid	4	4	16	32
	Cefaclor	8	2	8	16

Bc - Bacillus cereus (MTCC 1272); Sa - Staphylococcus aureus (MTCC 1144); Ec - Escherichia coli (MTCC 739); St - Salmonella typhi (MTCC 733). Cefaclor and linezolid are standard antibiotics.

Figure 2.  Comparison of MIC of complexes with standard antibiotics up to a concentration of 64 μg/mL.