Figures & data
Scheme 1. Reagents: (i) ethyl acetoacetate (1 mol for 4a, excess for 4b); Indium(III)chloride; reflux 2h;(ii) but-2-ynoic acid; DCC; DMAP; CH2Cl2 /DMF (10:1); r.t. 2h; (iii) PtCl4; 1,4-dioxane/1,2-dichloroethane (1:1); reflux 4h.
![Scheme 1. Reagents: (i) ethyl acetoacetate (1 mol for 4a, excess for 4b); Indium(III)chloride; reflux 2h;(ii) but-2-ynoic acid; DCC; DMAP; CH2Cl2 /DMF (10:1); r.t. 2h; (iii) PtCl4; 1,4-dioxane/1,2-dichloroethane (1:1); reflux 4h.](/cms/asset/d886a7cd-466c-462a-8eb1-c5062b80a7d8/ienz_a_369559_f0002_b.gif)
Figure 2. Percentage inhibition of NO production in LPS-induced RAW 264.7 macrophages for compounds 5a and 5b.
![Figure 2. Percentage inhibition of NO production in LPS-induced RAW 264.7 macrophages for compounds 5a and 5b.](/cms/asset/9986e163-aa37-4cde-ae08-e179f7ebe799/ienz_a_369559_f0004_b.gif)
Figure 3. Percentage inhibition of NO production in LPS induced RAW 264.7 macrophages for compounds 6a, 4a and 4b.
![Figure 3. Percentage inhibition of NO production in LPS induced RAW 264.7 macrophages for compounds 6a, 4a and 4b.](/cms/asset/9a93de7a-f077-4ddd-adf5-4ab7c70061a6/ienz_a_369559_f0005_b.gif)
Table I. IC50 values of inhibition of NO production in LPS-induced RAW 264.7 macrophages for compounds.
Table II. Radical scavenging activity of analyzed compounds.
Table III. Cytotoxic activities against human tumor cell lines of compounds.