Figures & data
Table 1. Functionalised amino acid derivatives (3–18).
Table 2. 1,8-Naphthyridine derivatives (22–62).
Table 3. In vitro cytotoxicity of 1,8-Naphthyridine derivatives (22–62).
Table 4. IC50 values for TNF-α modulation by selected 1,8-naphthyridine carboxamide derivatives. Molecules were subjected to screening over a multiple dose concentration range of 0.001 μg/mL to 10 μg /mL.
Figure 3. IL-1-β modulation of selected molecules. Dotted line shows IC50 (concentration at which 50% inhibition occurs).
![Figure 3. IL-1-β modulation of selected molecules. Dotted line shows IC50 (concentration at which 50% inhibition occurs).](/cms/asset/5f9e9b87-62d3-4ab9-8807-d63791f360eb/ienz_a_369850_f0005_b.gif)
Figure 4. MIP-1-α modulation of selected molecules. Dotted line shows IC50 (concentration at which 50% inhibition occurs).
![Figure 4. MIP-1-α modulation of selected molecules. Dotted line shows IC50 (concentration at which 50% inhibition occurs).](/cms/asset/9ed9e499-e4fc-4bcf-bf85-fc358f66ec34/ienz_a_369850_f0006_b.gif)
Figure 5. IP-10 modulation of selected molecules. Dotted line shows IC50 (concentration at which 50% inhibition occurs).
![Figure 5. IP-10 modulation of selected molecules. Dotted line shows IC50 (concentration at which 50% inhibition occurs).](/cms/asset/1c6b338b-4cb2-48c8-ba24-b89d523a6245/ienz_a_369850_f0007_b.gif)
Table 5. Downregulation of IP-10 levels to 50% (IC50) of selected 1,8-naphthyridine derivatives. Molecules were subjected to screening over a multiple dose concentration range of 0.001 μg/mL to 10 μg/mL.