A series of cinnamic acid derivatives and their inhibitory activity on intestinal α-glucosidase

Figures & data

Figure 1.  Structure of cinnamic acid (1) and its cinnamic acid derivatives (2–11).

Figure 2.  Percentage α-glucosidase inhibition of cinnamic acid and its derivatives. Data are expressed as mean ± SEM; n = 3.

Table 1.  IC₅₀ values for intestinal α-glucosidase (maltase and sucrase) inhibition by cinnamic acid derivatives.

Compound	IC50 value (mM)
	Maltase	Sucrase
8	0.74 ± 0.01	0.49 ± 0.01
10	0.79 ± 0.04	0.45 ± 0.01
11	0.76 ± 0.03	0.45 ± 0.01

Note. Results are expressed as mean ± SEM; n = 3.

Figure 3.  Lineweaver–Burk plots for inhibitory activity of (A) compound 8, (B) compound 10, and (C) compound 11 on intestinal maltase.

Figure 4.  Lineweaver–Burk plots for inhibitory activity of (A) compound 8, (B) compound 10, and (C) compound 11 on intestinal sucrase.

Figure 5.  Percentage enzyme inhibition of acarbose and its combination with compounds 8, 10, and 11 on (A) intestinal maltase and (B) intestinal sucrase. Results are expressed as mean ± SEM; n = 3. *p < 0.01 compared to acarbose alone.