Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

Krzysztof Z. ŁączkowskiDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland, Correspondence[email protected]

Anna BiernasiukDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University, Lublin, Poland,

Angelika Baranowska-ŁączkowskaInstitute of Physics, Kazimierz Wielki University, Bydgoszcz, Poland, and

Sylwia ZielińskaDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland,

Kinga SałatChair of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Krakow, Poland

Anna FurgałaChair of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University, Medical College, Krakow, Poland

Konrad MisiuraDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland,

Anna MalmDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University, Lublin, Poland,

show all

Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

Table 1. The antifungal activity data expressed as MIC [μg/ml] and, in parentheses, as MFC [μg/ml] for compounds 4a–v.

Table 2. The antibacterial activity data expressed as MIC [μg/ml] and, in parentheses, as MBC [μg/ml] for compounds 4a–v.

Table 3. Anticonvulsant activity of the test compounds in 6-Hz test.

Table 4. The B3LYP/6–31G relative energies, and the M06–2X/6–31G and M06–2X/6–311G interaction (ΔE) and binding (E_bind) energies of 4a–β-cyclodextrin complex.**

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

Figures & data

Table 1. The antifungal activity data expressed as MIC [μg/ml] and, in parentheses, as MFC [μg/ml] for compounds 4a–v.

Table 2. The antibacterial activity data expressed as MIC [μg/ml] and, in parentheses, as MBC [μg/ml] for compounds 4a–v.

Table 3. Anticonvulsant activity of the test compounds in 6-Hz test.

Table 4. The B3LYP/6–31G** relative energies, and the M06–2X/6–31G** and M06–2X/6–311G** interaction (ΔE) and binding (Ebind) energies of 4a–β-cyclodextrin complex.

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Table 4. The B3LYP/6–31G relative energies, and the M06–2X/6–31G and M06–2X/6–311G interaction (ΔE) and binding (E_bind) energies of 4a–β-cyclodextrin complex.**