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Review Article

Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease

, , , , , , , & show all
Pages 572-587 | Received 14 Apr 2016, Accepted 28 Jun 2016, Published online: 29 Jan 2017

Figures & data

Figure 1. Drugs approved for the treatment of AD.

Figure 1. Drugs approved for the treatment of AD.

Figure 2. The chemical structure of multitarget-directed tacrine derivatives.

Figure 2. The chemical structure of multitarget-directed tacrine derivatives.

Figure 3. The chemical structures of tacrine derivatives as cholinesterase and Aβ aggregation inhibitors.

Figure 3. The chemical structures of tacrine derivatives as cholinesterase and Aβ aggregation inhibitors.

Figure 4. The chemical structures of tacrine derivatives as cholinesterase and BACE1 inhibitors.

Figure 4. The chemical structures of tacrine derivatives as cholinesterase and BACE1 inhibitors.

Figure 5. The chemical structures of tacrine derivatives with cholinesterase inhibition and antioxidant properties.

Figure 5. The chemical structures of tacrine derivatives with cholinesterase inhibition and antioxidant properties.

Figure 6. The chemical structures of tacrine derivatives with cholinesterase inhibition and NO-releasing properties.

Figure 6. The chemical structures of tacrine derivatives with cholinesterase inhibition and NO-releasing properties.

Figure 7. The chemical structures of tacrine derivatives as cholinesterase inhibitors with neuroprotective properties.

Figure 7. The chemical structures of tacrine derivatives as cholinesterase inhibitors with neuroprotective properties.

Figure 8. The chemical structures of tacrine derivatives as cholinesterase inhibitors with metal-chelating properties.

Figure 8. The chemical structures of tacrine derivatives as cholinesterase inhibitors with metal-chelating properties.

Figure 9. The chemical structures of tacrine derivatives with cholinesterase and MAO inhibitory activities.

Figure 9. The chemical structures of tacrine derivatives with cholinesterase and MAO inhibitory activities.

Figure 10. The chemical structures of tacrine derivatives as cholinesterase and tau-aggregation inhibitors.

Figure 10. The chemical structures of tacrine derivatives as cholinesterase and tau-aggregation inhibitors.