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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 32, 2017 - Issue 1
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Review Article

Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease

Wen-Yu WuJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; View further author information
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Yu-Chen DaiJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; View further author information
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Nian-Guang LiJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; Correspondence[email protected] [email protected] [email protected]
View further author information
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Ze-Xi DongJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; View further author information
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Ting GuJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; View further author information
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Zhi-Hao ShiJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Organic Chemistry, China Pharmaceutical University, Nanjing, Jiangsu, ChinaView further author information
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Xin XueJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; View further author information
,
Yu-Ping TangJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; Correspondence[email protected] [email protected] [email protected]
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Jin-Ao DuanJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; ;Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; Correspondence[email protected] [email protected] [email protected]
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Pages 572-587 | Received 14 Apr 2016, Accepted 28 Jun 2016, Published online: 29 Jan 2017

Figures & data

Figure 1. Drugs approved for the treatment of AD.

Figure 1. Drugs approved for the treatment of AD.

Figure 2. The chemical structure of multitarget-directed tacrine derivatives.

Figure 2. The chemical structure of multitarget-directed tacrine derivatives.

Figure 3. The chemical structures of tacrine derivatives as cholinesterase and Aβ aggregation inhibitors.

Figure 3. The chemical structures of tacrine derivatives as cholinesterase and Aβ aggregation inhibitors.

Figure 4. The chemical structures of tacrine derivatives as cholinesterase and BACE1 inhibitors.

Figure 4. The chemical structures of tacrine derivatives as cholinesterase and BACE1 inhibitors.

Figure 5. The chemical structures of tacrine derivatives with cholinesterase inhibition and antioxidant properties.

Figure 5. The chemical structures of tacrine derivatives with cholinesterase inhibition and antioxidant properties.

Figure 6. The chemical structures of tacrine derivatives with cholinesterase inhibition and NO-releasing properties.

Figure 6. The chemical structures of tacrine derivatives with cholinesterase inhibition and NO-releasing properties.

Figure 7. The chemical structures of tacrine derivatives as cholinesterase inhibitors with neuroprotective properties.

Figure 7. The chemical structures of tacrine derivatives as cholinesterase inhibitors with neuroprotective properties.

Figure 8. The chemical structures of tacrine derivatives as cholinesterase inhibitors with metal-chelating properties.

Figure 8. The chemical structures of tacrine derivatives as cholinesterase inhibitors with metal-chelating properties.

Figure 9. The chemical structures of tacrine derivatives with cholinesterase and MAO inhibitory activities.

Figure 9. The chemical structures of tacrine derivatives with cholinesterase and MAO inhibitory activities.

Figure 10. The chemical structures of tacrine derivatives as cholinesterase and tau-aggregation inhibitors.

Figure 10. The chemical structures of tacrine derivatives as cholinesterase and tau-aggregation inhibitors.

Related Research Data

Synthesis of thiazolidin-4-ones and thiazinan-4-ones from 1-(2-aminoethyl)pyrrolidine as acetylcholinesterase inhibitors.
Source: Taylor & Francis
Tacrine hybrids as multi-target-directed ligands in Alzheimer’s disease: influence of chemical structures on biological activities
Source: Springer Science and Business Media LLC
Tacrine congeners: cholinesterase inhibition and cytotoxic activity
Source: Wiley

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