Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats

Rana Abu FarhaFaculty of Pharmacy, The University of Jordan, Amman, Jordan and Correspondence[email protected]

Yasser BustanjiFaculty of Pharmacy, The University of Jordan, Amman, Jordan and

Yusuf Al-HiariFaculty of Pharmacy, The University of Jordan, Amman, Jordan and

Tariq Al-QirimFaculty of Pharmacy, Alzaytoonah University of Jordan, Amman, Jordan

Ghassan Abu ShiekhaFaculty of Pharmacy, Alzaytoonah University of Jordan, Amman, Jordan

Rabab AlbashitiFaculty of Pharmacy, The University of Jordan, Amman, Jordan and

Figures & data

Figure 1. Schematic representation of the rational of the study.

Scheme 1. Preparation of N-(benzoylphenyl)pyridine-3-carboxamide derivatives (C4, C6, C8, C10, C12, and C14). (i) SOCl₂, dry benzene, refluxed at 70 °C for 48 h, distillation to get rid from excess SOCl₂ and dry benzene, (ii) refluxed at 70 °C for 18 h, followed by the addition of 1,4-dioxane and stirring for 24 h.

Scheme 1. Preparation of N-(benzoylphenyl)pyridine-3-carboxamide derivatives (C4, C6, C8, C10, C12, and C14). (i) SOCl2, dry benzene, refluxed at 70 °C for 48 h, distillation to get rid from excess SOCl2 and dry benzene, (ii) refluxed at 70 °C for 18 h, followed by the addition of 1,4-dioxane and stirring for 24 h.

Figure 2. Effect of Triton WR-1339 on lipid profile after 18 h. Values are means ± SEM from six rats in each group. TG: triglyceride; TC: total cholesterol. *p Value < 0.01 using Mann–Whitney U test.

Table 1. Determination of compound (C8) acute toxicity using 5 different doses (200, 400, 600, 800, and 1000 mg/kg). Experiment was conducted on 5 groups of BALB/c mice (6 mice per each group).

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Table 2. Effect of the novel C4, C6, C8, C10, C12, C14, FF, and NA on plasma lipid levels in Triton WR-1339-induced hyperlipidemic rats after 18 h.

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Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats

Table 1. Determination of compound (C8) acute toxicity using 5 different doses (200, 400, 600, 800, and 1000 mg/kg). Experiment was conducted on 5 groups of BALB/c mice (6 mice per each group).

Table 2. Effect of the novel C4, C6, C8, C10, C12, C14, FF, and NA on plasma lipid levels in Triton WR-1339-induced hyperlipidemic rats after 18 h.

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Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats

Figures & data

Table 1. Determination of compound (C8) acute toxicity using 5 different doses (200, 400, 600, 800, and 1000 mg/kg). Experiment was conducted on 5 groups of BALB/c mice (6 mice per each group).

Table 2. Effect of the novel C4, C6, C8, C10, C12, C14, FF, and NA on plasma lipid levels in Triton WR-1339-induced hyperlipidemic rats after 18 h.

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