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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 32, 2017 - Issue 1
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Original Article

Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines

Halise Inci GulDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey; Correspondence[email protected]
,
Ebru MeteDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey; Correspondence[email protected]
,
Parham TaslimiDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey;
,
Ilhami GulcinDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey; ;Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; ORCID Iconhttp://orcid.org/0000-0001-5993-1668
ORCID Icon &
Claudiu T. SupuranNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy
Pages 189-192 | Received 14 Aug 2016, Accepted 30 Sep 2016, Published online: 24 Oct 2016

Figures & data

Scheme 1. Synthetic pathway of the benzenesulfonamides, 9–16.

Scheme 1. Synthetic pathway of the benzenesulfonamides, 9–16.

Table 1. Human CA isoenzymes (hCA I and II) inhibition value of the compounds (9–16) by the esterase method with 4-nitrophenyl acetate as substrate.

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