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Research Paper

Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives

, , , , , , , , & show all
Pages 746-758 | Received 16 Mar 2017, Accepted 04 Apr 2017, Published online: 24 May 2017

Figures & data

Scheme 1. General synthesis of the derivatives 133.

Scheme 1. General synthesis of the derivatives 1–33.

Figure 1. Invasion assay of ferrocene-based thiazolidinone derivatives (10 μM). VHL: vehicle (DMSO). *Significant inhibition of tachyzoite invasion (p ≤ .05, two-tailed Students’ t test). **Significant inhibition of tachyzoite attachment (p ≤ .05, two-tailed Students’ t test). Data are compiled from results of three independent experiments.

Figure 1. Invasion assay of ferrocene-based thiazolidinone derivatives (10 μM). VHL: vehicle (DMSO). *Significant inhibition of tachyzoite invasion (p ≤ .05, two-tailed Students’ t test). **Significant inhibition of tachyzoite attachment (p ≤ .05, two-tailed Students’ t test). Data are compiled from results of three independent experiments.

Figure 2. Replication assay of ferrocene-based thiazolidinone derivatives (10 μM). VHL: vehicle (DMSO); Tz: tachyzoites. Data are compiled from results of three independent experiments.

Figure 2. Replication assay of ferrocene-based thiazolidinone derivatives (10 μM). VHL: vehicle (DMSO); Tz: tachyzoites. Data are compiled from results of three independent experiments.

Table 1. Five-day growth inhibition assay for N-substituted thiazolidinone derivatives 133 and reference drugs.

Supplemental material

IENZ_1316494_Supplementary_Material.pdf

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