Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme

Figures & data

Figure 1. Pyrrole containing drugs.

Figure 2. Chemical structures of tested compounds.

Figure 3. Synthesis pathway of the tested compounds.

Figure 4. Reaction of arylhydrazine hydrochloride salts with N-methylpyrrole.

Table 1. IC₅₀ values obtained from regression analysis graphs for GR enzyme.

Compound	IC50 (µM)
8a	4.942
8b	1.402
8c	1.663
8d	1.050
8e	1.498
8i	1.422
8m	0.104
8n	0.678
8o	1.435
8q	0.846
8r	1.792
N,N-bis(2-chloroethyl)-N-nitrosourea	645

Mean from at least three determinations. Errors in the range of ±3% of the reported value (data not shown).