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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Review Article

Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy

Yuyan Lina Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, ChinaView further author information
,
Tao Zhoub School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, ChinaView further author information
,
Renren Baic College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Yuanyuan Xiea Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China;c College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, ChinaCorrespondence[email protected]
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Pages 1080-1099 | Received 31 Dec 2019, Accepted 09 Apr 2020, Published online: 24 Apr 2020

Figures & data

Figure 1. PSs that entered clinical trials.

Figure 1. PSs that entered clinical trials.

Figure 2. Photosensitisation process and mechanism of action of PDT.

Figure 2. Photosensitisation process and mechanism of action of PDT.

Figure 3. Backbone chemical structure of porphyrin.

Figure 3. Backbone chemical structure of porphyrin.

Figure 4. Structures of porphyrin conjugates 5–12.

Figure 4. Structures of porphyrin conjugates 5–12.

Figure 5. Structures of cationic porphyrin derivatives 13–19.

Figure 5. Structures of cationic porphyrin derivatives 13–19.

Figure 6. Structures of porphyrin conjugates 20–24.

Figure 6. Structures of porphyrin conjugates 20–24.

Figure 7. Structures of porphyrin conjugates 25–29.

Figure 7. Structures of porphyrin conjugates 25–29.

Figure 8. Structures of porphyrin conjugates 30 and 31.

Figure 8. Structures of porphyrin conjugates 30 and 31.

Figure 9. Structures of porphyrin conjugates 32 and 33.

Figure 9. Structures of porphyrin conjugates 32 and 33.

Figure 10. PA-conjugated porphyrin derivatives 34.

Figure 10. PA-conjugated porphyrin derivatives 34.

Figure 11. Glycoconjugated porphyrin derivatives 35–40.

Figure 11. Glycoconjugated porphyrin derivatives 35–40.

Figure 12. Porphyrin–zinc complexes 41–46.

Figure 12. Porphyrin–zinc complexes 41–46.

Figure 13. Porphyrin–platinum complexes 47–54.

Figure 13. Porphyrin–platinum complexes 47–54.

Figure 14. Porphyrin–ruthenium conjugates 55–57.

Figure 14. Porphyrin–ruthenium conjugates 55–57.

Figure 15. Porphyrin–ruthenium conjugates 58–60.

Figure 15. Porphyrin–ruthenium conjugates 58–60.

Figure 16. Porphyrin–gold, gadolinium, indium, and rhenium complexes 61–67.

Figure 16. Porphyrin–gold, gadolinium, indium, and rhenium complexes 61–67.

Figure 17. Peptide-coupled porphyrin derivatives 68–75.

Figure 17. Peptide-coupled porphyrin derivatives 68–75.

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