The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes

Figures & data

Table 1. IC₅₀ values for cardiac drugs of human carbonic anhydrase I and II

COMPOUNDS	IC50 (µM) (hydratase) hCA I	IC50 (µM) (hydratase) hCA II	IC50 (µM) (esterase) hCA I	IC50 (µM) (esterase) hCA II
1. Ranolazine	503	544	600	645
2. Propafenone	228	235	2.80	3.02
3. Nifedipine	77.9	103	42.2	50.6
4. Diltiazem	624	477	232	325
5. Trimetazidine dihydrochloride	196	151	112	112
6. Carvedilol	61.2	79	20.2	46.4
7. Amlodipine	133	126	38.5	38.8
8. Captopril	121	131	1.58	6.25
9. Edoxaban	94	67	45.5	34.2
10. Doxazosin mesylate	228	215	303	417
11. Ivabradine	503	544	107	117
12. Ramipril	281	154	32.3	37.9
13. indapamide	276	198	90	124
14. Lercanidipine hydrochloride	201	159	294	423
15. Nebivolol hydrochloride	73.7	95.3	404	410
16. Bisoprolol hemifumarate	107	221	156	244
17. Isosorbide mononitrate	160	160	6.08	5.50
18. Candesartan cilexetil	185	271	342	177
19. Irbesartan	235	239	345	335
20. Rivaroxaban	220	204	189	244
21. Ticagrelor	168	195	54	52.1
22. Furosemide	120	178	6.23	4.95
23. Clopidogrel	250	364	94	103
24. Digoxin	74.9	88	23.1	32.8
25. Propranolol	1.77	1.44	1.58	6.25
26. Amiodorane hydrochloride	389	405	8.47	12.4
27. Metoprolol succinate	400	168	319	329
28. Acetylsalicylic acid	252	246	43	58.3
29. Atorvastatin	243	390	7.75	9.85
30. Prasugrel	155	205	330	429
31. Apixaban	88.4	110	384	386
32. Lacidipine	696	482	150	155
33. Dabigatran etexilate	113	116	15.3	15.3
34. Glyceryl trinitrate	220	272	x	x
35. Lidocaine HCl	19.6	2	x	x

Table 2. IC₅₀ and K_i values of propafenone for hCA I and hCA II

Propafenone	IC50(µM) (Hydratase)	IC50(µM) (Esterase)	Kİ (µM) (Esterase)
hCA I	228	2.80	2.38
hCA II	235	3.02	2.97

Inhibition type is non-competitive inhibition.