Figures & data
Table 1. Types and subfamilies of topoisomerases
Figure 1. General mechanism of action of topoisomerase I (a) Top I binds to the DNA, (b) single-strand DNA (in blue) splitting, (c) controlled rotation of free DNA strand (in red), (d) religation of cleaved DNA strand.
![Figure 1. General mechanism of action of topoisomerase I (a) Top I binds to the DNA, (b) single-strand DNA (in blue) splitting, (c) controlled rotation of free DNA strand (in red), (d) religation of cleaved DNA strand.](/cms/asset/c38cdd92-088e-42dd-b55e-cdf946f2caa4/ienz_a_1821676_f0001_c.jpg)
Figure 2. General mechanism of action of topoisomerase II (a) topoisomerase binds to the G-segment, (b) Top IIA- G-segment complex binds to T-segment, (c) Two ATP molecules are attached to the resulting complex, (d) G-segment cleavage in presence of Mg2+ ions, (e) T-segment transport through the created gap, (f) T-segment release and religation of G-segment broken strands and (g) hydrolysis of ATP molecules and release of the G-segment.
![Figure 2. General mechanism of action of topoisomerase II (a) topoisomerase binds to the G-segment, (b) Top IIA- G-segment complex binds to T-segment, (c) Two ATP molecules are attached to the resulting complex, (d) G-segment cleavage in presence of Mg2+ ions, (e) T-segment transport through the created gap, (f) T-segment release and religation of G-segment broken strands and (g) hydrolysis of ATP molecules and release of the G-segment.](/cms/asset/483b8161-2a9c-47f1-8402-330abc499b82/ienz_a_1821676_f0002_c.jpg)
Table 2. Clinically relevant topoisomerases inhibitors
Table 3. Selected topoisomerase inhibitors under clinical investigation