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Review Article

Application of triazoles in the structural modification of natural products

, , &
Pages 1115-1144 | Received 06 Dec 2020, Accepted 08 Feb 2021, Published online: 24 Jun 2021

Figures & data

Figure 1. Chemical structures of 1,2,3-triazole and 1,2,4-triazole motifs.

Figure 1. Chemical structures of 1,2,3-triazole and 1,2,4-triazole motifs.

Figure 2. Some of the drugs available in the market containing 1,2,3-triazole ring.

Figure 2. Some of the drugs available in the market containing 1,2,3-triazole ring.

Figure 3. The chemical structures of anti-lung cancer compounds 1–5.

Figure 3. The chemical structures of anti-lung cancer compounds 1–5.

Figure 4. The chemical structures of anti-breast cancer compounds 6–11.

Figure 4. The chemical structures of anti-breast cancer compounds 6–11.

Figure 5. The chemical structures of anti-gastric cancer compounds 12–13.

Figure 5. The chemical structures of anti-gastric cancer compounds 12–13.

Figure 6. The chemical structures of anti-ovarian cancer compound 14, anti-liver cancer compounds 15–16, and anti-pancreatic cancer compound 17.

Figure 6. The chemical structures of anti-ovarian cancer compound 14, anti-liver cancer compounds 15–16, and anti-pancreatic cancer compound 17.

Figure 7. The chemical structures of anti-colon cancer compounds 18–20.

Figure 7. The chemical structures of anti-colon cancer compounds 18–20.

Figure 8. The chemical structures of anti-leukaemia compounds 21–23.

Figure 8. The chemical structures of anti-leukaemia compounds 21–23.

Figure 9. The chemical structures of anti-multiple cancer cells compounds 24–43.

Figure 9. The chemical structures of anti-multiple cancer cells compounds 24–43.

Figure 10. The chemical structures of anti-inflammatory compounds 44–49.

Figure 10. The chemical structures of anti-inflammatory compounds 44–49.

Figure 11. The chemical structures of antibacterial compounds 50–58.

Figure 11. The chemical structures of antibacterial compounds 50–58.

Figure 12. The chemical structures of antifungal compounds 59–60.

Figure 12. The chemical structures of antifungal compounds 59–60.

Figure 13. The chemical structures of anti-multiple timicrobial compounds 61–62.

Figure 13. The chemical structures of anti-multiple timicrobial compounds 61–62.

Figure 14. The chemical structures of anti-leishmanial compounds 63–65.

Figure 14. The chemical structures of anti-leishmanial compounds 63–65.

Figure 15. The chemical structures of antimalarial compounds 66–71.

Figure 15. The chemical structures of antimalarial compounds 66–71.

Figure 16. The chemical structures of anti-Toxoplasma gondii compounds 72–74.

Figure 16. The chemical structures of anti-Toxoplasma gondii compounds 72–74.

Figure 17. The chemical structure of anti-Trypanosoma cruzi compound 75.

Figure 17. The chemical structure of anti-Trypanosoma cruzi compound 75.

Figure 18. The chemical structures of anti-multiple parasitic compounds 76–77.

Figure 18. The chemical structures of anti-multiple parasitic compounds 76–77.

Figure 19. The chemical structures of antiviral compounds 78–79.

Figure 19. The chemical structures of antiviral compounds 78–79.

Figure 20. The chemical structures of antioxidant compounds 80–81.

Figure 20. The chemical structures of antioxidant compounds 80–81.

Figure 21. The chemical structures of anti-Alzheimer compounds 82–91.

Figure 21. The chemical structures of anti-Alzheimer compounds 82–91.

Figure 22. The chemical structures of enzyme inhibitors 92–94.

Figure 22. The chemical structures of enzyme inhibitors 92–94.