https://orcid.org/0000-0001-6455-5716
Figures & data
Figure 1. Structure of coumarin I, its hydrolysed form II, some reported coumarin-based CAIs III–V, some reported pyridine derivatives bearing chalcone functionality VI–IX, and target compounds 5a–o.
Scheme 1. Reagents and conditions: (i) Dry toluene, reflux 7 h.; (ii) Acetylacetone, CH3COONH4, AcOH, reflux 10 h.
Scheme 2. Reagents and conditions: (i) KOH (aq.), dioxane: MeOH stirring at 0 °C 2 h then r.t overnight.
Table 1. Inhibition data of MPC 3 and 5a–o against hCA isoforms I, II, IX, and XII using AAZ as a reference. 
Table 2. Selectivity ratios for MPC 3 and MPCs 5a–o towards cancer-related hCA isoforms.
Table 3. Cell growth inhibition (GI%) of 59 human tumour cell lines in vitro at a dose of 10 µM for MPCs 5g and 5l.
Figure 2. The best anti-proliferative activities exerted by target MPC chalcones 5a–f, 5h–k, and 5m–o.
Table 4. Results of the five-dose anticancer assay for MPC 5l against all fifty-nine cancer cell lines.