Figures & data
Table 1. Geometrical Parameters of selected compounds.
Table 2. Energetic parameters that predict reactivity of compounds.
Table 3. IC50 values of compounds 6(a–j) values of alkaline phosphatase inhibitory activity.
Figure 4. Alkaline phosphatase inhibition by compounds 6g as shown by Lineweaver-Burk plots (a). The plot of the slope vs inhibitor concentrations to get the inhibition constant is shown in the insets (b). Using the linear least squares fit, the lines were drawn.
![Figure 4. Alkaline phosphatase inhibition by compounds 6g as shown by Lineweaver-Burk plots (a). The plot of the slope vs inhibitor concentrations to get the inhibition constant is shown in the insets (b). Using the linear least squares fit, the lines were drawn.](/cms/asset/a888611d-d1a5-4b3a-836c-e5a845220607/ienz_a_2163394_f0004_c.jpg)
Table 4. Kinetic parameters of the alkaline phosphatase for para nitrophenyl phosphate disodium salt activity in the presence of different concentrations of 6g.
Table 5. Binding energies of the potent inhibitors of alkaline phosphatase.
Figure 5. Illustrating the 3D and 2D binding interactions of potent compounds (6d, 6e, 6g, 6i and 6j).
![Figure 5. Illustrating the 3D and 2D binding interactions of potent compounds (6d, 6e, 6g, 6i and 6j).](/cms/asset/36f68a2f-563b-4b6d-82c7-5a90377c2ecb/ienz_a_2163394_f0005_c.jpg)
Figure 6. RMSD trajectory analysis for protein (brown coloured trajectory), protein ligand complex (blue coloured trajectory).
![Figure 6. RMSD trajectory analysis for protein (brown coloured trajectory), protein ligand complex (blue coloured trajectory).](/cms/asset/6b0060f4-43c2-472d-974e-6fc10f6aa3bf/ienz_a_2163394_f0006_c.jpg)
Supplemental Material
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